Yes, you can fully customize the message sent by your autoresponder in cPanel or your email client.
You can include:
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A personalized greeting
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Information about your unavailability (e.g. vacation or business hours)
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Alternative contact details
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Any other relevant instructions or responses
This allows you to tailor the autoresponder for different situations—whether it’s an out-of-office notice, a vacation reply, or a confirmation of message receipt.